Our skeleton performs much more than the function of support for our muscles and other tissues. Bone secretes the hormone osteoclastine , which directly regulates insulin production and carbohydrate metabolism, and can significantly affect the risk of diabetes.
Scientists from the University of Montreal, Canada, have been studying the effects of osteoclast for more than 10 years. Recently, the authoritative journal of Clinical Investigation published interesting data from their latest observations. According to them, a detailed study of osteoclast can help in developing agents for the treatment of type 2 diabetes and obesity .
Bones as an active endocrine organ
It is well known that hormones affect the strength and structure of the bones. For example, estrogen is among the main regulators of bone health in women, and its deficiency leads to osteoporosis . However, the study of Canadian scientists reveals interesting details of the feedback features – how bones regulate the hormonal balance of the body.
Bone secreted osteoclastine may stimulate insulin production in the pancreas and facilitate the absorption of glucose. This not only reduces the risk of diabetes, but also increases energy consumption and prevents obesity. The study of Canadian scientists shows that normal secretion of osteoclastin is important for the prevention of type 2 diabetes almost as much as insulin production.
Osteoclastin is secreted into osteoblasts , the same cells that produce the bone substance. Hormone accumulates in them in an inactive form. After secretion of a sufficient amount of a special enzyme complex called furine , it removes part of the osteoclast molecule, which actually activates the hormone. His release into the blood follows.
It has been found that a number of factors can inhibit the synthesis of the enzyme complex or deactivate it, thereby inhibiting the production of active osteoclastin . In such cases, insulin secretion is also insufficient – evidence that insulin secretion is directly related to hormone levels produced in the bones.
This discovery allows scientists to identify yet another potential cause of diabetes . On the other hand, regulating osteoclastin secretion may be used in the future as a complementary treatment for diabetes in many patients.